Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort: ELSA-Brasil study

Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort: ELSA-Brasil study

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Abstract: Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance.HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index edgewater shoes (BMI) levels.We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Among the 12,313 participants with mean age of 51.

2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity.

The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%.The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate 2014 dodge ram 1500 fender flares the metabolic syndrome was 2.

35 in the whole sample, with increasing values at higher BMI categories.This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy.It also suggests that different values might be appropriate across BMI categories.